Novel molecules can be used to treat the microbial infections including resistance microorganisms. DNA gyrase is an essential enzyme belongs to a class of topisomerases IV which is essential for DNA synthesis leads to DNA transcription and replication. Sterol 14α-demethylase is an enzyme that transferred the electrons from one molecule to another and catalyses the oxidation or reduction reactions. The compounds AIA-II, AIA-I and DP-1 were showed potent against the DNA gyrase with glide score -11.37, -8.94 and -8.53 as compared with standard amikacin, ciprofloxacin and streptomycin with glide score -13.88, -9.28 and -8.37. The compounds AIA-I and AIA-II were showed more potent against the sterol 14α-demethylase with glide score 11.13 and -10.07 as compared with standard amikacin and ciprofloxacin with glide score -9.87 and -5.85.
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